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William J Israelsen Selected Research

Pyruvate Kinase

1/2022Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma.
1/2020Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity.
6/2017Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.
1/2017PKM2 is not required for colon cancer initiated by APC loss.
1/2016Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.
7/2015Pyruvate kinase: Function, regulation and role in cancer.
1/2015Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.
10/2013PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
10/2012Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
11/20112-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.

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William J Israelsen Research Topics

Disease

9Neoplasms (Cancer)
01/2020 - 11/2010
1Shock
06/2022
1Adenocarcinoma
01/2022
1Hyperglycemia
06/2017
1Mitochondrial Diseases (Mitochondrial Disease)
06/2017
1Colonic Neoplasms (Colon Cancer)
01/2017
1Inflammation (Inflammations)
01/2016
1Hepatocellular Carcinoma (Hepatoma)
01/2016
1Carcinogenesis
10/2012

Drug/Important Bio-Agent (IBA)

10Pyruvate KinaseIBA
01/2022 - 11/2011
7Protein Isoforms (Isoforms)IBA
01/2017 - 11/2011
4Glucose (Dextrose)FDA LinkGeneric
06/2017 - 11/2010
3EnzymesIBA
01/2020 - 11/2011
1Proteins (Proteins, Gene)FDA Link
06/2022
1Lactic Acid (Lactate)FDA LinkGeneric
06/2022
1ML-265IBA
06/2017
1Messenger RNA (mRNA)IBA
06/2017
1CateninsIBA
01/2017
1IsoenzymesIBA
11/2011
1Adenosine Triphosphate (ATP)IBA
11/2010